Systemic Lupus Erythematosus (SLE or Lupus) General Info: Quote: Systemic lupus erythematosus (SLE) can cause various symptoms, the most common being joint pains, skin rashes and tiredness. Problems with kidneys and other organs can occur in severe cases. Treatment includes anti-inflammatory painkillers to ease joint pains. Steroids and/or other medication is sometimes also needed. Lupus is a condition characterized by chronic inflammation of body tissues caused by autoimmune